1011_INDEPENDENT STUDIES IN MEMBRANE BIOLOGY & SIGNAL TRANSDUCTION(I)
Course Period:FromNow ~ Any Time
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Course Intro

Course Plan

  • Curvature recognition and force generation in phagocytosis
  • Localised PtdIns(3,4,5)P3 or PtdIns(3,4)P2 at the phagocytic cup is required for both phagosome closure and Ca2+ signalling in HL60 neutrophils
  • Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes
  • Myo1c binds phosphoinositides through a putative PH domain
  • Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis
  • Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis
  • Expression of Y53A-actin in Dictyostelium disrupts the cytoskeleton and inhibits intracellular and intercellular chemotactic signaling
  • Myosin X is a downstream effector of PI(3)K during phagocytosis
Co-Instructor(s)
陳俊霖

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